In our recent question and also answer, the pharmacist discusses even if it is or not Tylenol PM can safely it is in taken through Benadryl.

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Joseph asked

I take Tylenol PM mostly every night yet it doesn"t constantly work. Deserve to I include Benadryl on peak of it for better effects?


It is not recommended to take Tylenol PM all at once with Benadryl. Acquisition these drugs together outcomes in duplicate drug therapy of the medication diphenhydramine together both Tylenol PM and Benadryl save on computer it as an active ingredient. Sheep of each must be be separated be in ~ least four to six hours.

Tylenol PM

Tylenol pm is a medicine which contains:


The ache reliever ingredient of this medication (acetaminophen) is valuable for the treatment of mild come moderate pain. The device of acetaminophen is not quite understood but is believed to inhibit prostaglandins which offer a duty in inflammation and also pain.

The antihistamine component (diphenhydramine) is beneficial for aiding in sleep or allergic rhinitis symptoms as result of the anticholinergic impact that antihistamines exert top top the body. This medication, if offered as a sleep aid, is recommended to it is in taken about one hour prior to the preferred hour that sleep.

Each sheep (e.g. Tablet, capsule) of Tylenol PM has 500 mg that acetaminophen and 25 mg the diphenhydramine.


Unlike Tylenol PM, Benadryl only includes diphenhydramine which is a first generation antihistamine. First-generation antihistamines are known for your sedative impacts and reasonably short duration of action. The usual uses the this medication space for allergy relief, insomnia and also the avoidance or therapy of activity sickness. The exact same anticholinergic, sedating and drowsy side effects are meant with this medication just like Tylenol PM.

Each dose of Benadryl (e.g. Tablet, capsule) includes 25 mg that diphenhydramine.

Taking Benadryl through Tylenol PM

The usage of these drugs together will result in one additive result of toxicities and not in therapeutic advantage as both drugs contain diphenhydramine in the energetic ingredients. Effects which might be intensified include:

SedationDrowsinessDry mouthDry eyesConstipation

When acquisition either of this medications, that is recommended to take them at night time because of the potential come induce sleep. The use of heavy machinery or operation vehicles is additionally not encourage while using either of these medications.

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Lastly, the is vital to keep in mind that some sources indicate the dosage of Benadryl because that the therapy of insomnia to it is in 50 mg, or 2 tablets. Therefore, if necessary, you have the right to safely take oneBenadryl tablet with Tylenol pm to equal a dose of 50 mg the diphenhydramine, however this would certainly be the maximum dose. This likewise isn"t typically recommended as result of the hazard of overdosing using multiple medications.