*
Two rhesus macaques (Macaca mulatta) in ~ the animal husbandry at the German Primate Center. The rhesus aspect of human being blood was uncovered through experiments through such animals. Photo: Anton Säckl


You are watching: How did the discovery of the rhesus factor affect society

The name suggests that this properties of the human being blood originates native the findings of pet experiments with monkeys: Rhesus element derives from the rhesus monkey (Macaca mulatta). This monkeys also have the factor, and also the surname is as result of the use of red blood cell from the blood of rhesus monkeys to acquire the first test serum. Serum is the watery substance that is separated native the clotted blood. Around 1940, the Austrian knife Landsteiner and his colleague Alexander Wiener want to uncover out why, the most important human blood group system "AB0", which had previously to be discovered, sometimes had actually shock effects and in some situations fatal results after blood transfusions. They want to discover out why the immune equipment of some world had allergic reactions after ~ a transfusion.

For this, they take it blood indigenous rhesus monkeys, which are very comparable to humans and with that, they "vaccinated" guinea pigs. The rodents developed a protective substance against the international substance in your blood. Native the guinea-pig"s blood, the researchers once again got serum, which they added to a hundred human being blood samples, every from a various donor. The results: around 85 the the samples clumped, 15 continued to be unaffected. The rhesus aspect was discovered and became the 2nd most necessary blood group system for humans.

The rhesus element can it is in harmful (even fatal) to people in two various situations: in blood transfusions and in pregnancies. Surface proteins ~ above the envelope of the red blood cells (erythrocytes) which some human beings possess and others do not, space responsible because that the rhesus factor: positive ("Rh +") through the proteins, an adverse ( "Rh-") without. Around 15 percent of all Europeans perform not have actually this element in their blood. The surface ar proteins ensure the the blood that rhesus-positive humans is viewed as international bodies during a blood transfer from the immune device of the rhesus-negative person in bespeak to form antibodies against it. A put in order blood transfusion can lead come a life-threatening reaction that the immune mechanism of the recipient.


In this video the 2 most necessary blood group systems, AB0 and also rhesus factor, are described in detail.


A similar constellation well-known as rhesus incompatibility can take place in women v multiple pregnancies: that occurs once a rhesus-negative woman is pregnant through a rhesus-positive kid with the equivalent father. The rhesus-negative biology of the female creates antibodies versus the Rhesus-positive erythrocytes during the very first pregnancy and also during the next pregnancy hemolysis wake up in the child. Hemolysis, is described by medical professionals as the dissolution of red blood cells, which, amongst other things, bring about the absence of oxygen supply to the fetus. This have the right to have fatal consequences for the child and also in many situations it causes serious health problems. Follow to the doctor Reinhard Roos, statistically together a constellation wake up in approximately every tenth pregnancy, the danger of together a pregnancy pertains to a high number of pregnant women.

The routine testing of blood groups, which has actually been possible since the exploration of the rhesus factor, saved plenty of babies in the womb and likewise recipients that blood transfusions native severe risks during significant surgery. There is no the use of rhesus monkeys in an easy research, this would not have actually been possible. Like countless other researchers who were dependence on pet experiments, karl Landsteiner obtained the Nobel compensation in medication for his life-saving results.




See more: Incline Dumbbell Front Raise On Incline Bench, Dumbbell, Front Raises: Prone On Incline Bench, Dumbbell

More information around the Rh disease on Wikipedia

Biography around Karl Landsteiner

How the Rhesus aspect can influence pregnancy

Information about Rh Incompatibility (NIH)


Deutsches Primatenzentrum GmbH Leibniz-Institut für Primatenforschung Kellnerweg 4 37077 Göttingen Germany